The Impact of Impaired Kidney Function and HIV Infection on the Risk of Anemia
Year: 2012
Type: article
Abstract: Chronic kidney disease and HIV infection both independently increase the risk of anemia. It is not known if individuals with both HIV infection and kidney dysfunction are at greater than expected risk of anemia resulting from the combined effect of these factors. Men from the Multicenter AIDS Cohort Study with AIDS-free time after 1996 were included in the analysis if they had an initial hemoglobin value greater than 13 g/dl and available serum creatinine measurements for the estimation of glomerular filtration rate. Hemoglobin data were fit parametrically using a linear mixed effects model and effects of medication use on hemoglobin levels were removed using censoring methods. The effect of both HIV infection and glomerular filtration rate less than 60 ml/min/1.73 m(2) on the mean hemoglobin value was assessed. The risk of having anemia (hemoglobin level falling below 13 g/dl) was estimated. There were 862 HIV-infected and 1,214 HIV-uninfected men who contributed to the analysis. Hemoglobin values across all 17,341 person-visits, adjusting for age, were generally lower in HIV-infected AIDS-free men with impaired kidney function by -0.22 g/dl (95% CI: -0.42, -0.03) compared to men with either HIV infection or impaired kidney function, but not both. HIV-infected AIDS-free men with impaired kidney function have a higher risk of anemia by 1.2% compared to HIV-uninfected men with normal kidney function. Comorbid conditions and medication use did not explain this increase in risk. HIV infection and impaired kidney function have a combined impact on lowering hemoglobin levels, resulting in a higher risk of anemia.
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Northwestern University, Johns Hopkins University, University of Pittsburgh, Deutsches Krebsforschungszentrum, University of California, Los Angeles, Johns Hopkins Bloomberg School of Public Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources
Awards: G141124744, G1648982045, G1705418768, G2017072594, G2533091585, G344188330, G359857122, General Clinical Research Center, Natural History of AIDS in Homosexual Men, G4330383484, G4698605015, MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH, G51363488, University of Pittsburgh Multicenter AIDS Cohort Study (MACS), Center/Coordination, Analysis and Management/MACS, G555535742, G6035818063, G6120741853, G622133462, Burden of Chronic Kidney Disease in HIV Infection, MULTICENTER AIDS COHORT STUDY PATHOGENESIS RESEARCH LABS, Multicenter AIDS Cohort Study, G7030869821, G714446084, G7240936510, General Clinical Research Center, Multicenter AIDS Cohort Study - Part B (Baltimore Center), G939135972
OpenAlex ID: W2050467681