Work

Hippo signaling: growth control and beyond

Year: 2010

Type: review

Abstract: The Hippo pathway has emerged as a conserved signaling pathway that is essential for the proper regulation of organ growth in Drosophila and vertebrates. Although the mechanisms of signal transduction of the core kinases Hippo/Mst and Warts/Lats are relatively well understood, less is known about the upstream inputs of the pathway and about the downstream cellular and developmental outputs. Here, we review recently discovered mechanisms that contribute to the dynamic regulation of Hippo signaling during Drosophila and vertebrate development. We also discuss the expanding diversity of Hippo signaling functions during development, discoveries that shed light on a complex regulatory system and provide exciting new insights into the elusive mechanisms that regulate organ growth and regeneration.

Source: Development

DOI: 10.1242/dev.045500

Authors: Georg Halder, Randy L. Johnson

Institutions: The University of Texas MD Anderson Cancer Center, Baylor College of Medicine

Language: English

Topic: Hippo pathway signaling and YAP/TAZ

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Cancer Research Institute, Cancer Prevention and Research Institute of Texas, National Institutes of Health

OpenAlex ID: W2050712486

FWCI: 4.797

Cites: 192

Cited by: 1,095

Related to: 10