Work

Enantioselective α-Arylation of Carbonyls via Cu(I)-Bisoxazoline Catalysis

Year: 2011

Type: article

Abstract: The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja206050b

Authors: James S. Harvey, Scott P. Simonovich, Christopher R. Jamison, David W. C. MacMillan

Institution: Princeton University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: Photoredox Catalysis Applications in Organometallics and Chemical Biology, G1588828791