Year: 2012
Type: review
Abstract: Neurological disorders can be modeled in animals so as to recreate specific pathogenic events and behavioral outcomes. Parkinson's Disease (PD) is the second most common neurodegenerative disease of an aging population, and although there have been several significant findings about the PD disease process, much of this process still remains a mystery. Breakthroughs in the last two decades using animal models have offered insights into the understanding of the PD disease process, its etiology, pathology, and molecular mechanisms. Furthermore, while cellular models have helped to identify specific events, animal models, both toxic and genetic, have replicated almost all of the hallmarks of PD and are useful for testing new neuroprotective or neurorestorative strategies. Moreover, significant advances in the modeling of additional PD features have come to light in both classic and newer models. In this review, we try to provide an updated summary of the main characteristics of these models as well as the strengths and weaknesses of what we believe to be the most popular PD animal models. These models include those produced by 6-hydroxydopamine (6-OHDA), 1-methyl-1,2,3,6-tetrahydropiridine (MPTP), rotenone, and paraquat, as well as several genetic models like those related to alpha-synuclein, PINK1, Parkin and LRRK2 alterations.
Source: BioMed Research International
DOI: 10.1155/2012/845618
Institution: Columbia University
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $2,680
Awards: G1878477771, SPINAL MUSCULAR ATROPHY (SMA): DISEASE PHENOTYPE AND MECHANISM, Proinflammatory enzymes in amytrophic lateral sclerosis, Pre-clinical testing of necrostatin as a potential small molecule for the treatme, G4119534169, Mechanisms of dopamine neuron degeneration, G4758779210, G5530522899, G5850682332, PD iPS Cell Line Research Consortium, G6593266840, A novel cell-based high-throughput assay for ALS, G6871073102, G7100573593, INTERACTION OF SYNCLEIN AND INFLAMMATION IN DOPAMINERGIC NEURODEGENERATION, G7842377153, G7873927678, NEUROPROTECTIVE SMALL MOLECULES FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSSI, G956766560
OpenAlex ID: W2050865611