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A novel non‐parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib‐pairs

Year: 2008
Type: article
Study design: Observational Study
Abstract: In this report, we present results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Study on the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel smoothing for our analysis. We report a statistically significant linkage close to the ADH gene cluster on Chromosome 4. We also obtain evidence for epistatic interaction between a region on Chromosome 1 and one on Chromosome 15. Although alcoholism as a covariate does not have any effect on the linkage scan, it has an effect on the epistatic interaction.
DOI: 10.1002/ajmg.b.30735
Authors: Saurabh Ghosh, Laura J. Bierut, Bernice Porjesz, Howard J. Edenberg, Danielle Dick, Alison Goate, Victor Hesselbrock, John Nurnberger, Tatiana Foroud, John Kramer, John Rice, Henri Begleiter
Institutions: Washington University in St. Louis, Indian Statistical Institute, SUNY Downstate Health Sciences University, Indiana University School of Medicine, University of Connecticut, UConn Health, University of Iowa
Language: English
Subfield: Genetics
Open Access status: green
Funders: State University of New York, Washington University in St. Louis, University of Connecticut, National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, Fogarty International Center
OpenAlex ID: W2050867595
FWCI: 0.176
Cites: 39
Cited by: 6
Related to: 10