Work

Reply To: Δ4-3-Oxosteroid 5β-reductase deficiency and neonatal hemochromatosis

Year: 1994

Type: letter

Abstract: Dr. Clayton's letter raises pertinent points with regard to the interpretation of the finding of increased urinary excretion of Δ4-3- oxo bile acids. These metabolites can be detected in a variety of severe cholestatic liver disorders. The interpretation of their presence in liver failure is much more complex. Currently the finding of high proportions of Δ4-3-oxo bile acids and markedly reduced or absent primary bile acids is used as supportive evidence of a quantitative defect in Δ4-3-oxosteroid 5β-reductase enzyme activity.

Source: The Journal of Pediatrics

DOI: 10.1016/s0022-3476(06)80204-0

Authors: Kenneth D. R. Setchell, Benjamin L. Shneider, Frederick J. Suchy, Peter F. Whitington

Institutions: Cincinnati Children's Hospital Medical Center, Yale University, University of Chicago

Language: English

Topic: Pediatric Hepatobiliary Diseases and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,570

OpenAlex ID: W2051014486

Cites: 4

Cited by: 2

Related to: 10