Work

Review NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings

Year: 2007

Type: article

Abstract: An increasing number of RNAs are being discovered that perform their functions by undergoing large changes in conformation in response to a variety of cellular signals, including recognition of proteins and small molecular targets, changes in temperature, and RNA synthesis itself. The measurement of NMR residual dipolar couplings (RDCs) in partially aligned systems is providing new insights into the structural plasticity of RNA through combined characterization of large‐amplitude collective helix motions and local flexibility in noncanonical regions over a wide window of biologically relevant timescales ( This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected]

Source: Biopolymers

DOI: 10.1002/bip.20765

Authors: Melissa Getz, Xiaoyan Sun, Anette Casiano‐Negroni, Qi Zhang, Hashim M. Al‐Hashimi

Institution: University of Michigan

Language: English

Topic: RNA and protein synthesis mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green