Work

Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae

Year: 2014

Type: review

Abstract: The Gram-negative opportunistic pathogen, Klebsiella pneumoniae, is responsible for causing a spectrum of community-acquired and nosocomial infections and typically infects patients with indwelling medical devices, especially urinary catheters, on which this microorganism is able to grow as a biofilm. The increasingly frequent acquisition of antibiotic resistance by K. pneumoniae strains has given rise to a global spread of this multidrug-resistant pathogen, mostly at the hospital level. This scenario is exacerbated when it is noted that intrinsic resistance to antimicrobial agents dramatically increases when K. pneumoniae strains grow as a biofilm. This review will summarize the findings about the antibiotic resistance related to biofilm formation in K. pneumoniae.

Source: Pathogens

DOI: 10.3390/pathogens3030743

Authors: Claudia Vuotto, Francesca Longo, Maria Balice, Gianfranco Donelli, Pietro Varaldo

Institutions: Marche Polytechnic University, Fondazione Santa Lucia

Language: English

Topic: Bacterial biofilms and quorum sensing

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,654