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Cell Sorting: Microfluidic Cell Sorter (μFCS) for On‐chip Capture and Analysis of Single Cells (Adv. Healthcare Mater. 4/2012)

Year: 2012

Type: article

Abstract: Many cancers shed malignant cells into the circulation. These cancer cells are important for both diagnostic and therapeutic purposes but their purification, quantification and characterization remain challenging. On page 432, Hakho Lee, Ralph Weissleder, and co-workers present a low-cost, rapid microfluidic cell sorter (μFCS) device for the detection and molecular analysis of circulating tumor cells (CTCs). The μFCS efficiently enriches CTCs from unprocessed whole blood, allows on-chip culture and molecular profiling, and provides cell retrieval for subsequent analyses. The potential clinical application of the technology is demonstrated by capturing and genetically analyzing CTCs in tumorbearing mice.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.201290018

Authors: Jaehoon Chung, Huilin Shao, Thomas Reiner, David Issadore, Ralph Weissleder, Hakho Lee

Institutions: Massachusetts General Hospital, Center for Systems Biology, Harvard University

Language: English

Topic: Microfluidic and Bio-sensing Technologies

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2051274142

FWCI:

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