Year: 2005
Type: review
Abstract: Structural and functional alterations in the Ca2+ regulatory proteins present in the sarcoplasmic reticulum have recently been shown to be strongly involved in the pathogenesis of heart failure. Chronic activation of the sympathetic nervous system or of the renin-angiotensin system induces abnormalities in both the function and structure of these proteins. We review here the considerable body of evidence that has accumulated to support the notion that such abnormalities contribute to a defectiveness of contractile performance and hence to the progression of heart failure.
DOI: 10.1172/jci24159
Institution: Yamaguchi University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Normalization of increased protein phosphatase 1 activity by using an high efficiency myocardial gene transfer technique in chronic heart failure, Acquisition of resistance against heart failure by incorporation of ryanodine receptor stabilizing peptide to cardiomyocyte, Development of gene therapy for treatment of dilated cardiomyopathy and associated heart failure, Development of molecular therapy correcting abnormal intracellular Ca^<2+> regulation in chronic heart failure
OpenAlex ID: W2051304606