Work

Sensing Dna With Alternating Currents Using a Nanogap Sensor Embedded in a Nanochannel Device

Year: 2013

Type: article

Abstract: We report an integrated nanochannel/nanoelectrode sensor for the detection of DNA using alternating currents. We find that DNA can be detected using platinum as the metal for the detecting electrodes, with a signal to noise ratio exceeding 10. We argue that the signal is at least in part electrochemical in nature, thus holds the promise to yield a sequence-dependent signal. However, we also find that for large voltages, DNA attaches irreversibly to the driving electrodes.

Source: Nano LIFE

DOI: 10.1142/s1793984413400072

Authors: BRET H. DAVIS, JUNHAN PAN, CHIH-KUAN TUNG, ROBERT H. AUSTIN, ROBERT RIEHN

Institutions: North Carolina State University, Princeton University

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Human Genome Research Institute

Award: Sequencing DNA by transverse electrical measurements in Nanochannels