Work

Towards ultrahigh throughput microinjection: MEMS-based massively-parallelized mechanoporation

Year: 2012

Type: conference-paper

Abstract: We describe a massively-parallelized, MEMS-based device concept for passively delivering exogeneous molecules into living cells via mechanical membrane penetration, i.e., mechanoporation. Details regarding device design and fabrication are discussed, as are results from preliminary live cell studies focused on device validation at the proof-of-concept level. These efforts represent key steps towards our long-term goal of developing instrumentation capable of ultrahigh throughput (UHT) cellular manipulation via active microinjection.

Source: Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

DOI: 10.1109/embc.2012.6346001

Authors: Yanyan Zhang, C. B. Ballas, M. P. Rao

Institutions: University of California, Riverside, Indiana University Indianapolis, Indiana University School of Medicine

Language: English

Topic: Advanced MEMS and NEMS Technologies

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Center for Research Resources

Awards: Ultrahigh throughput cellular manipulation via massively parallel microinjection, Ultrahigh throughput cellular manipulation via massively parallel microinjection, G96696820