Work

Aptamer-Functionalized Nanoparticles for Medical Applications: Challenges and Opportunities

Year: 2012

Type: article

Abstract: With advances in aptamer selection technologies and nanomedicine, aptamer-functionalized nanoparticles are being explored as promising platforms for targeted therapeutic and diagnostic applications. In this Perspective, we outline recent progress in this field, as exemplified by Bamrungsap et al. in this issue of ACS Nano. Furthermore, we highlight the challenges and opportunities in translating current proof-of-concept designs into in vivo applications, with emphasis on the intrinsic properties of aptamers and their interplay with nanoparticles. With continuous efforts, we expect aptamer-functionalized nanoparticles to advance from preclinical into clinical development for further evaluation.

Source: ACS Nano

DOI: 10.1021/nn301869z

Authors: Zeyu Xiao, Omid C. Farokhzad

Institutions: Brigham and Women's Hospital, Harvard University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Biomedical Imaging and Bioengineering