Work

Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries.

Year: 1993

Type: article

Abstract: An iterative strategy for the selection of catalytic metalloantibodies is described. The first stage of this strategy is validated by the selection of semisynthetic antibodies that coordinate a variety of different metal ions and the metal oxide magnetite. These results have implications not only for the development of catalytic metalloantibodies but also for the development of reagents for magnetic resonance imaging, delivery of radioisotopes, and purification of recombinant proteins.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.90.14.6385

Authors: C F Barbas, J S Rosenblum, R A Lerner

Institution: Scripps Research Institute

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Science Foundation

OpenAlex ID: W2051604859

FWCI: 10.26

Cites: 22

Cited by: 103

Related to: 10