Year: 2005
Type: article
Abstract: MICROSYMPOSIA C119antibiotics is acquired mainly by target alterations but in a few cases, the antibiotic chemical moieties are modified; that the primary action of most antibiotics that induce significant local or allosteric conformational alterations is to inhibit functional activities rather than to merely block vital locations; and that most proteins that interact with antibiotics are involved in dynamic aspects of ribosomal function.Although a precise understanding of all processes associated with antibiotic action is still incomplete, the current findings justify modest optimism and it appears that the elucidation of the common principles, combined with the genetic, structural, and biochemical investigations should lead to structure-based approaches for devising modifications of existing antibiotics as well as in the design of novel potent antiinfective drugs.
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2051728146