Work

Total Marrow and Lymph Node Irradiation (TMLI) with Fludarabine (FLU) and Melphalan (MEL) Is Well Tolerated and May Result in Improved Outcome in Patients (PTS) with Advanced Hematological Malignancies

Year: 2009

Type: article

Abstract: Reduced intensity conditioning (RIC) with FLU/MEL followed by hematopoietic stem cell transplantation (HSCT) may result in long-term survival in pts with hematologic malignancies and compromised organ function (COF); however, pts with advanced disease do poorly with RIC alone (Giralt, Biol. Blood Marrow Transplant, 13:884, 2007). In an attempt to improve the anti-tumor efficacy of RIC, while maintaining a low-toxicity profile, we added TMLI to FLU/MEL. We hypothesize that Flu/Mel with 1200 cGY of TMLI delivered using Tomotherapy Hi-Art system is safe, tolerable, and may improve outcome in pts with COF and advanced hematological malignancies.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2008.12.325

Authors: J. Rosenthal, J. Wong, A. Stein, H. Naeem, D. Hitt, S. Forman

Institutions: City Of Hope National Medical Center, City of Hope

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650