Work

Entrapment of Hydrophobic Drugs in Nanoparticle Monolayers with Efficient Release into Cancer Cells

Year: 2009

Type: article

Abstract: Gold nanoparticles functionalized with water-soluble zwitterionic ligands form kinetically stable complexes with hydrophobic drugs and dyes. These drugs and dyes are efficiently released into cells, as demonstrated through fluorescence microscopy and cytotoxicity assays. Significantly, there is little or no cellular uptake of particle, making these low toxicity particles promising for delivery applications.

Source: Journal of the American Chemical Society

DOI: 10.1021/ja808137c

Authors: Chae Kyu Kim, Partha Ghosh, Chiara Pagliuca, Zheng-Jiang Zhu, Stefano Menichetti, Vincent M. Rotello

Institutions: University of Massachusetts Amherst, University of Florence

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of General Medical Sciences