Work

Organic Carbamates in Drug Design and Medicinal Chemistry

Year: 2015

Type: review

Abstract: The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug-target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry.

Source: Journal of Medicinal Chemistry

DOI: 10.1021/jm501371s

Authors: Arun K. Ghosh, Margherita Brindisi

Institution: Purdue University West Lafayette

Language: English

Topic: Chemical Synthesis and Analysis

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: Purdue University, National Institute of General Medical Sciences