Work

Partitioning Viral Genomes in Mitosis: Same Idea, Different Targets

Year: 2006

Type: article

Abstract: Papillomavirus infections are long-lived and persistent. The circular DNA of the viral genome is maintained in dividing epithelial cells as an extrachromosomal element. The E2 protein of the virus binds to the viral genome and tethers it to mitotic chromosomes to ensure that the genome is retained and faithfully partitioned in dividing cells. This mechanism has been best studied for bovine papillomavirus type 1. Recent evidence indicates that while this is a common strategy among papillomaviruses, different viruses have selected different chromosomal targets.

Source: Cell Cycle

DOI: 10.4161/cc.5.14.3094

Authors: Alison A. McBride, Jaquelline G. Oliveira, Maria G. McPhillips

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Funder: National Institutes of Health

OpenAlex ID: W2052018973

FWCI: 2.661

Cites:

Cited by: 68

Related to: 10