Work

Polar opposites: Fine‐tuning cytokinesis through SIN asymmetry

Year: 2012

Type: review

Abstract: Mitotic exit and cell division must be spatially and temporally integrated to facilitate equal division of genetic material between daughter cells. In the fission yeast, Schizosaccharomyces pombe, a spindle pole body (SPB) localized signaling cascade termed the septation initiation network (SIN) couples mitotic exit with cytokinesis. The SIN is controlled at many levels to ensure that cytokinesis is executed once per cell cycle and only after cells segregate their DNA. An interesting facet of the SIN is that its activity is asymmetric on the two SPBs during anaphase; however, how and why the SIN is asymmetric has remained elusive. Many key factors controlling SIN asymmetry have now been identified, shedding light on the significance of SIN asymmetry in regulating cytokinesis. In this review, we highlight recent advances in our understanding of SIN regulation, with an emphasis on how SIN asymmetry is achieved and how this aspect of SIN regulation fine-tunes cytokinesis.

Source: Cytoskeleton

DOI: 10.1002/cm.21044

Authors: Alyssa E. Johnson, Dannel McCollum, Kathleen L. Gould

Institutions: Vanderbilt University, University of Massachusetts Chan Medical School, Howard Hughes Medical Institute

Language: English

Topic: Microtubule and mitosis dynamics

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute of General Medical Sciences

Awards: Regulation of Hippo pathway signaling by mechanical forces, Cellular, Biochemical and Molecular Sciences Training Program, G2659027680, G8072298061