Year: 2002
Type: article
Study design: Observational Study
Abstract: Recently, linkage analysis of a series of familial chronic lymphocytic leukaemia (CLL) showed that affected sibling pairs did not share common major histocompatibilty complex haplotypes. We analysed Class I and II antigens in 11 Italian families with familial CLL. Although there was no association of disease status with any particular human leucocyte antigen, there was an overrepresentation of DRB1 11 alleles in these families (P = 0.009). A similar trend was also observed in a second series of nine French families (P = 0.002). Larger studies are needed to determine whether non-inherited paternal or maternal DRB1 antigens play a role in familial CLL development.
Source: British Journal of Haematology
Authors: Ioannis Theodorou, Laurent Abel, Francesca Mauro, Brigitte Duprey, Christian Magnac, Béatrice Payelle‐Brogard, Frederic Davi, Guillaume Dighiero
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2052052413