Work

Proteomic identification of nitrated brain proteins in amnestic mild cognitive impairment: a regional study

Year: 2007

Type: article

Abstract: Oxidative stress is an imbalance between the level of antioxidants and oxidants in a cell. Oxidative stress has been shown in brain of subjects with mild cognitive impairment (MCI) as well Alzheimer's disease (AD). MCI is considered as a transition phase between control and AD. The focus of the current study was to identify nitrated proteins in the hippocampus and inferior parietal lobule (IPL) brain regions of subjects with amnestic MCI using proteomics. The identified nitrated proteins in MCI brain were compared to those previously reported to be nitrated and oxidatively modified in AD brain, a comparison that might provide an invaluable insight into the progression of the disease.

Source: Journal of Cellular and Molecular Medicine

DOI: 10.1111/j.1582-4934.2007.00065.x

Authors: Rukhsana Sultana, Tanea Reed, Marzia Perluigi, Rafaella Coccia, William M. Pierce, D. Allan Butterfield

Institutions: University of Kentucky, Sapienza University of Rome, University of Louisville

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: University of Kentucky, National Institute on Aging