Year: 2011
Type: letter
Abstract: To the Editor: We share the concerns that Rappaport et al. express in their Perspective article in this issue of the Journal regarding possible relationships between anesthetic agents and neurologic damage in young children. However, clinicians are challenged with extrapolating neurodevelopmental stages and behavioral correlates from animal models to human infants. Studies in animals reveal worrisome neuronal apoptosis after anesthesia, raising questions about whether pediatric anesthesiologists should change their practice and what they should tell parents. Studies in animals involve prolonged exposure to anesthetics in high doses with variable monitoring and no surgical stress. Furthermore, translating stages of brain development . . .
Source: New England Journal of Medicine
DOI: 10.1056/nejmc1102479
Authors: Nancy L. Glass, Shobha Malviya
Institution: Society for Pediatric Anesthesia
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2052209777