Work

Susceptibility Pathways in Fanconi's Anemia and Breast Cancer

Year: 2010

Type: review

Abstract: Fanconi's anemia is a rare disorder that arises from defective repair of damaged DNA. Of the 13 Fanconi's anemia genes, 3 are breast-cancer–susceptibility genes. One is identical to BRCA2. Cells from patients with the D1 subtype of Fanconi's anemia and their family members carry biallelic mutations in BRCA2, and heterozygote members of kindreds with the D1 subtype have an increased risk of breast and ovarian cancer. Studies of a rare disorder can thus illuminate a common disorder.

Source: New England Journal of Medicine

DOI: 10.1056/nejmra0809889

Author: Alan D. D'Andrea

Institutions: Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green