Work

Predictive Models Using NIH Criteria and Clinical Characteristics Define Diagnosis, Disease Activity and Risk Factors for Chronic Ocular Graft-Versus Host Disease

Year: 2015

Type: article

Abstract: Ocular chronic GVHD (cGVHD) is one of the most bothersome and common long-term complications after allogeneic HCT. The 2005 NIH cGVHD Consensus Project provided expert recommendations for diagnosis: dry, gritty, or painful eyes, cicatricial conjunctivitis, keratoconjunctivitis sicca or confluent areas of punctate keratopathy in conjunction with abnormally low Schirmer’s tear test. However these have not been prospectively validated in patients. The goal of this analysis was to identify predictive models for ocular cGVHD diagnosis, disease activity and clinical correlates that could be feasibly employed by transplant clinicians to assess outcomes in clinical practice and therapeutic trials.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2014.11.522