Work

Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells

Year: 2005

Type: review

Abstract: The field of vascular biology has been stimulated by the concept that circulating endothelial progenitor cells (EPCs) may play a role in neoangiogenesis (postnatal vasculogenesis). One problem for the field has been the difficulty in accurately defining an EPC. Likewise, circulating endothelial cells (CECs) are not well defined. The lack of a detailed understanding of the proliferative potential of EPCs and CECs has contributed to the controversy in identifying these cells and understanding their biology in vitro or in vivo. A novel paradigm using proliferative potential as one defining aspect of EPC biology suggests that a hierarchy of EPCs exists in human blood and blood vessels. The potential implications of this view in relation to current EPC definitions are discussed.

Source: Blood

DOI: 10.1182/blood-2005-04-1509

Authors: David A. Ingram, Noel M. Caplice, Mervin C. Yoder

Institutions: Mayo Clinic, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis

Language: English

Topic: Angiogenesis and VEGF in Cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2052488548