The vessel wall and its interactions
Year: 2008
Type: review
Abstract: Blood cell interactions with the vessel wall were first documented almost 170 years ago. Modern advances have revealed that leukocyte and platelet interactions with the endothelium are at the nexus of complex, dynamic cellular and molecular networks that, when dysregulated, may lead to pathological inflammation and thrombosis, which are major sources of morbidity and mortality in the Western world. In this review, we relate the history of blood cell interactions with the vasculature, discuss recent progress, and raise some unresolved questions awaiting the field.
Source: Blood
Authors: Denisa D. Wagner, Paul S. Frenette
Institutions: Harvard University, Icahn School of Medicine at Mount Sinai
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Molecular Analysis of Cardiovascular Biology and Pathology, Regulation and function of hematopoietic stem cell niches, WEIBEL PALADE BODY FORMATION AND ROLE IN HEMOSTASIS, In vivo mechanisms mediating sickle cell vaso-occlusion and organ damage, Adhesion Molecules in Transfusion Biology, Assay development for high throughput screening of selectin ligand antagonists
OpenAlex ID: W2052547401