Work

Programmed cell death in the tobacco hornworm, Manduca sexta: Alteration in protein synthesis

Year: 1996

Type: article

Abstract: The metamorphic death of the labial glands of the tobacco hornworm, Manduca sexta, occurs during a 4 day period during larva-to-pupa metamorphosis. The earliest changes marking the death of the cell, all occurring on the first day, are a sharp drop in protein synthesis, coupled with the selective survival or upregulation of a few messages. An early rearrangement of the rough endoplasmic reticulum is presumably related to the generalized decrease in protein synthesis. Lysosomal acid phosphatase also begins to increase very early, and ultimately the bulk of the cytoplasm is destroyed in autophagic vacuoles, but activation of lysosomes does not account for the decreased rate of synthesis. The mechanism by which most protein synthesis is depressed remains under investigation.

Source: Microscopy Research and Technique

DOI: 10.1002/(sici)1097-0029(19960615)34:3<192::aid-jemt2>3.0.co;2-s

Authors: Zahra Zakeri, Daniela Quaglino, Theresa Latham, Kim Woo, Richard A. Lockshin

Institutions: Queens College, CUNY, University of Modena and Reggio Emilia, St. John's University, The Graduate Center, CUNY

Language: English

Topic: Cell death mechanisms and regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: U.S. Public Health Service

Award: G1934824580