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The bile acid TGR5 membrane receptor: From basic research to clinical application

Year: 2014
Type: review
Abstract: The TGR5 receptor (or GP-BAR1, or M-BAR) was characterized ten years ago as the first identified G-coupled protein receptor specific for bile acids. TGR5 gene expression is widely distributed, including endocrine glands, adipocytes, muscles, immune organs, spinal cord, and the enteric nervous system. The effect of TGR5 activation depends on the tissue where it is expressed and the signalling cascade that it induces. Animal studies suggest that TGR5 activation influences energy production and thereby may be involved in obesity and diabetes. TGR5 activation also influences intestinal motility. This review provides an overview of TGR5-bile acid interactions in health as well as the possible involvement of TGR5 in human disease.
DOI: 10.1016/j.dld.2013.10.021
Institutions: Inserm, University of California, Los Angeles, Université Paris Cité, Hôpital Louis-Mourier, Sorbonne Paris Cité, Hôpital Saint-Antoine, VA Greater Los Angeles Healthcare System, Laboratoire des Biomolécules, Université Paris Diderot, University of California San Diego
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,300
OpenAlex ID: W2052638070
FWCI: 4.75
Cites: 97
Cited by: 490
Related to: 10