Work

α-Azido Bisphosphonates: Synthesis and Nucleotide Analogues

Year: 2011

Type: article

Abstract: The first examples of α-azido bisphosphonates [(RO)(2)P(O)](2)CXN(3) (1, R = i-Pr, X = Me; 2, R = i-Pr, X = H; 3, R = H, X = Me; 4, R = H, X = H) and corresponding β,γ-CXN(3) dGTP (5-6) and α,β-CXN(3) dATP (7-8) analogues are described. The individual diastereomers of 7 (7a/b) were obtained by HPLC separation of the dADP synthetic precursor (14a/b).

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo200045a

Authors: Brian T. Chamberlain, Thomas G. Upton, Boris A. Kashemirov, Charles E. McKenna

Institution: University of Southern California

Language: English

Topic: Organophosphorus compounds synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, University of California, Riverside, National Cancer Institute

Awards: G5796009091, DNA Polymerase Fidelity Mechanisms: Theory and Experiment