Work

The Goldilocks Principle and Antibiotic Resistance in Bacteria

Year: 2011

Type: article

Abstract: We have designed and fabricated a microecology to mimic a naturally occurring bacterial culture, which includes the stress gradient, metapopulation, and cellular motility. In this microecology, we show that it is possible to fix the resistance to the mutagenic antibiotic Ciprofloxacin in wild-type Escherichia coli within 10 h. We found the evolution of resistance is further accelerated in microecology if bacteria have already acquired the phenotype of growth advantage at the stationary phase (GASP).

Source: Molecular Pharmaceutics

DOI: 10.1021/mp200274r

Authors: Qiucen Zhang, Kristelle Robin, David Liao, Guillaume Lambert, Robert H. Austin

Institutions: Princeton University, Hong Kong University of Science and Technology, University of California, San Francisco

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Cancer Institute

Award: Explosive Evolution Under Stress: The Driving Forces of Cancer Dynamics (Main)