Work

Biosynthesis of fungal indole alkaloids

Year: 2014

Type: article

Abstract: This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to incorporate and derivatize the indole/indoline moieties in various families of fungal indole alkaloids will be discussed, including tryptophan-containing nonribosomal peptides, polyketide-nonribosomal peptide hybrids, and alkaloids derived from other indole building blocks. This review also includes a discussion regarding the downstream modifications that generate chemical and structural diversity among indole alkaloids.

Source: Natural Product Reports

DOI: 10.1039/c4np00073k

Authors: Wei Xu, Diego J. Gavia, Yi Tang

Institution: University of California, Los Angeles

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases, National Center for Chronic Disease Prevention and Health Promotion

Awards: G2040174267, G2072215212, Rediscovering Natural Chemical Diversity, G845586035