Work

Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene.

Year: 1985

Type: article

Abstract: The entire nucleotide sequence of an infectious clone of human T-cell leukemia virus type II provirus was determined. This provirus consists of 8952 nucleotides. In addition to long terminal repeats and gag, pol, env, and X, a protease gene that is responsible for processing the gag precursor protein was found. The protease gene is encoded in a different frame from gag and pol and was located between the gag and pol open reading frames. The 5' region of the protease gene overlaps the 3' gag region. Coding regions of the provirus show about 60% homology with those of human T-cell leukemia virus type I at the nucleotide level. The evolutionary relationship between human T-cell leukemia virus types I and II is discussed.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.82.10.3101

Authors: K Shimotohno, Y Takahashi, N Shimizu, T Gojobori, D W Golde, I S Chen, M Miwa, T Sugimura

Institutions: National Institute of Genetics, National Cancer Center Research Institute, University of California, Los Angeles

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2052857807

FWCI: 11.05

Cites: 27

Cited by: 380

Related to: 10