Endocytosis Pathways for Nucleic Acid Therapeutics
Year: 2012
Type: article
Abstract: The development of nanoscale delivery vehicles for siRNAs is a current topic of considerable importance. However, little is understood about the exact trafficking mechanisms for siRNA-vehicle complexes across the plasma membrane and into the cytoplasm. While some information can be gleaned from studies on delivery of plasmid DNA, the different delivery requirements for these two vehicles makes drawing specific conclusions a challenge. However, using chemical inhibitors of different endocytosis pathways, studies on which endocytotic pathways are advantageous and deleterious for the delivery of nucleic acid drugs are emerging. Using this information as a guide, it is expected that the future development of effective siRNA delivery vehicles and therapeutics will be greatly improved.
Source: Nano LIFE
Institution: Michigan State University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: Engineering an in vitro model of adipose tissue formation and metabolism, Development of a parallel, array-based transcription factor expression assay, Phenotype-Targeted Inference of Flux-Enzyme Correlations in Adipocyte Metabolism, Develop a Dynamic Model that Incoporates Text-mining to Reconstruct Networks, Maximizing siRNA Function through Mechanism-based Sequence and Vehicle Design
OpenAlex ID: W2052871716