Work

Coating Optimization of Superparamagnetic Iron Oxide Nanoparticles for High T 2 Relaxivity

Year: 2010

Type: article

Abstract: We describe a new method for coating superparamagnetic iron oxide nanoparticles (SPIOs) and demonstrate that, by fine-tuning the core size and PEG coating of SPIOs, the T2 relaxivity per particle can be increased by >200-fold. With 14 nm core and PEG1000 coating, SPIOs can have T2 relaxivity of 385 s-1 mM-1, which is among the highest per-Fe atom relaxivities. In vivo tumor imaging results demonstrated the potential of the SPIOs for clinical applications.

Source: Nano Letters

DOI: 10.1021/nl102623x

Authors: Sheng Tong, Sijian Hou, Zhilan Zheng, Jun Zhou, Gang Bao

Institutions: Georgia Institute of Technology, Emory University

Language: English

Topic: Characterization and Applications of Magnetic Nanoparticles

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute