Work

Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins

Year: 2014

Type: review

Abstract: Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena, and they continue to attract interest due to their high potency, bioavailability, and fewer concerns with toxicity, drug to drug cross-reactions, and tissue accumulation.1,2 Although poor drug delivery and low in vivo stability are still issues to be addressed, peptides look poised to play an important role in the treatment of diseases ranging from Alzheimer's disease to cancer.2,3 The huge biodiversity offered by venom peptides, specially conotoxins isolated from the venom of predatory marine snails, holds enormous promise for the development of peptide-based drugs.

Source: Chemical Reviews

DOI: 10.1021/cr400401e

Authors: Kalyana B. Akondi, Markus Muttenthaler, Sébastien Dutertre, Quentin Kaas, David J. Craik, Richard J. Lewis, Paul F. Alewood

Institutions: The University of Queensland, Institute for Research in Biomedicine, Institute for Molecular Bioscience, Parc Científic de Barcelona, Centre National de la Recherche Scientifique, Institut des Biomolécules Max Mousseron, Université Montpellier 2

Language: English

Topic: Venomous Animal Envenomation and Studies

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2052956415

FWCI: 4.297

Cites: 345

Cited by: 331

Related to: 10