Work

Thyroid Autoantibodies in Pregnancy: Their Role, Regulation and Clinical Relevance

Year: 2013

Type: article

Abstract: Autoantibodies to thyroglobulin and thyroid peroxidase are common in the euthyroid population and are considered secondary responses and indicative of thyroid inflammation. By contrast, autoantibodies to the TSH receptor are unique to patients with Graves' disease and to some patients with Hashimoto's thyroiditis. Both types of thyroid antibodies are useful clinical markers of autoimmune thyroid disease and are profoundly influenced by the immune suppression of pregnancy and the resulting loss of such suppression in the postpartum period. Here, we review these three types of thyroid antibodies and their antigens and how they relate to pregnancy itself, obstetric and neonatal outcomes, and the postpartum.

Source: Journal of Thyroid Research

DOI: 10.1155/2013/182472

Authors: Francis S. Balucan, Syed A. Morshed, Terry F. Davies

Institutions: James J. Peters VA Medical Center, Icahn School of Medicine at Mount Sinai

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $950