Work

Intrabody and intrakine strategies for molecular therapy

Year: 2003

Type: review

Abstract: Utilizing advances in understanding protein expression and trafficking, a new therapeutic strategy for inhibiting protein expression has been developed. This strategy uses an intracellular antibody (“intrabody”) or intracellular chemokine (“intrakine”) to neutralize the function of target proteins. One of the primary methods of achieving this goal is by redirecting the target protein to an intracellular compartment, such as the endoplasmic reticulum (ER), where it may be trapped, thereby decreasing the surface expression or secretion of the protein.

Source: Molecular Therapy

DOI: 10.1016/s1525-0016(03)00183-7

Authors: Yurong Yang Wheeler, Si-Yi Chen, David C Sane

Institutions: Wake Forest University Health Sciences, Wake Forest University, Baylor College of Medicine

Language: English

Topic: Monoclonal and Polyclonal Antibodies Research

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,500