Work

Expression of the liver X receptor α and β in embryonic and adult mice

Year: 2004

Type: article

Abstract: We characterized the expression pattern of the nuclear receptors liver X receptor (LXR) alpha and beta during mouse embryonic development and in adulthood by in situ hybridization experiments. LXRalpha and LXRbeta are detected in the liver starting at 11.5 days postcoitum. Later, LXRalpha expression remains high in organs involved in lipid homeostasis, such as liver, intestine, and brown adipose tissue, whereas LXRbeta is more ubiquitously expressed and enriched in tissues of neuronal and endocrine origin.

Source: The Anatomical Record Part A Discoveries in Molecular Cellular and Evolutionary Biology

DOI: 10.1002/ar.a.20015

Authors: Jean‐Sébastien Annicotte, Kristina Schoonjans, Johan Auwerx

Institutions: Centre National de la Recherche Scientifique, Inserm, Institut de génétique et de biologie moléculaire et cellulaire, Phénotypage et ingénierie précliniques des systèmes d’organismes modèles

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: European Commission, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique