Work

Discovery of the cellular and molecular basis of cholesterol control

Year: 2013

Type: article

Abstract: The cellular control of cholesterol metabolism mediated by lipoproteins was first appreciated in pioneering work published in a 1974 PNAS Classic by Michael Brown and Joseph Goldstein. We know from this paper that the LDL binds to a cell surface receptor and dampens the activity of a key enzyme in cholesterol biosynthesis and that a receptor deficiency is responsible for a major genetic cause of hypercholesterolemia and premature atherosclerosis.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1312967110

Author: Randy Schekman

Institutions: Howard Hughes Medical Institute, University of California, Berkeley

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2053178951

FWCI: 1.962

Cites: 20

Cited by: 27

Related to: 10