Work

Control of inflammation by integration of environmental cues by regulatory T cells

Year: 2013

Type: review

Abstract: Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci57175

Authors: Ashutosh Chaudhry, Alexander Y. Rudensky

Institutions: Memorial Sloan Kettering Cancer Center, Howard Hughes Medical Institute

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Howard Hughes Medical Institute, Cancer Research Institute, Memorial Sloan-Kettering Cancer Center, National Institutes of Health