Work

Autophagy-dependent suppression of cancer immunogenicity and effector mechanisms of innate and adaptive immunity

Year: 2013

Type: article

Abstract: The inspection of the mechanisms through which autophagy modulates immunogenic cell death revealed that the autophagic response of cancer cells to reactive oxygen species-dependent endoplasmic reticulum stress suppresses the exposure of calreticulin on the cell surface, the phenotypic maturation of dendritic cells (DCs) as well as their ability to release interleukin-6 and to support the proliferative expansion of (interferon γ-producing) CD4+ and CD8+ T lymphocytes. These findings unveil an unprecedented role for therapy-induced autophagy in suppressing key mechanisms that underlie anticancer immune responses as elicited by immunogenic cell death.

Source: OncoImmunology

DOI: 10.4161/onci.26260

Authors: Abhishek D Garg, Aleksandra M Dudek, Patrizia Agostinis

Institution: KU Leuven

Language: English

Topic: Autophagy in Disease and Therapy

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,913