Work

Nodular lymphocyte predominant Hodgkin lymphoma at atypical locations may be associated with increased numbers of large cells and a diffuse histologic component

Year: 2007

Type: article

Abstract: Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) typically affects predictable lymph node groups with excellent treatment outcomes, but cases with a diffuse histologic pattern are associated with recurrence and rarely, cases will transform to diffuse large B-cell lymphoma. Although increased numbers of large cells has not been associated with poor prognosis, transformation is thought to histologically progress through a stage distinguished by increasing numbers of large atypical B-cells. From 55 cases of NLPHL, we describe a possible subset of NLPHL occurring in older individuals at atypical sites, associated with increased numbers of large cells, a diffuse histologic component, and expression of Bcl-2.

Source: American Journal of Hematology

DOI: 10.1002/ajh.21077

Authors: David T. Yang, Cherie H. Dunphy, Sheryl R. Tripp, Anand S. Lagoo, Sherrie L. Perkins

Institutions: University of Utah, University of Utah Health Care, University of North Carolina at Chapel Hill, ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories (United States), Duke University, Duke Medical Center

Language: English

Topic: Lymphoma Diagnosis and Treatment

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2053466194

FWCI: 0.448

Cites: 25

Cited by: 7

Related to: 10