Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1
Year: 2008
Type: article
Abstract: Dietary carbohydrates regulate hepatic lipogenesis by controlling the expression of critical enzymes in glycolytic and lipogenic pathways. We found that the transcription factor XBP1, a key regulator of the unfolded protein response, is required for the unrelated function of normal fatty acid synthesis in the liver. XBP1 protein expression in mice was elevated after feeding carbohydrates and corresponded with the induction of critical genes involved in fatty acid synthesis. Inducible, selective deletion of XBP1 in the liver resulted in marked hypocholesterolemia and hypotriglyceridemia, secondary to a decreased production of lipids from the liver. This phenotype was not accompanied by hepatic steatosis or compromise in protein secretory function. The identification of XBP1 as a regulator of lipogenesis has important implications for human dyslipidemias.
Source: Science
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Subfield: Biochemistry
Domain: Life Sciences
Open Access status: green
Awards: Arming the Immune System Against Pathogens, MOLECULAR PHYSIOLOGY OF BILIARY LIPID SECRETION, Transcriptional Regulation of the Immune Response, Phospholipid-Mediated Metabolic Control in the Pathogenesis of NAFLD, Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2, Lipid-Mediated Control of Acetyl-CoA Metabolism in the Pathogenesis of NAFLD, G923503880
OpenAlex ID: W2053500970