Work

Receptor protein tyrosine kinase DDR is up‐regulated by p53 protein

Year: 1996

Type: article

Abstract: We have previously reported on radiation-induction of ptk-3 in rat astrocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.

Source: FEBS Letters

DOI: 10.1016/s0014-5793(96)01234-3

Authors: Shirou Sakuma, Hideyuki Saya, Mitsuhiro Tada, Mitsuyoshi Nakao, Toshiyoshi Fujiwara, Jack A. Roth, Yutaka Sawamura, Yumiko Shinohe, Hiroshi Abe

Institutions: Hokkaido University, Kumamoto University, Okayama University

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2053515406

FWCI: 0.717

Cites: 19

Cited by: 38

Related to: 10