Work

Microelectromechanical systems scanning-mirror-based handheld probe for fluorescence molecular tomography

Year: 2012

Type: article

Abstract: A novel handheld probe based on a microelectromechanical systems (MEMS) scanning mirror for three-dimensional (3D) fluorescence molecular tomography (FMT) is described. The miniaturized probe consists of a MEMS mirror for delivering an excitation light beam to multiple preselected points at the tissue surface and an optical fiber array for collecting the fluorescent emission light from the tissue. Several phantom experiments based on indocyanine green, an FDA approved near-infrared (NIR) fluorescent dye, were conducted to assess the imaging ability of this device. Tumor-bearing mice with systematically injected tumor-targeted NIR fluorescent probes were scanned to further demonstrate the ability of this MEMS-based FMT for imaging small animals.

Source: Applied Optics

DOI: 10.1364/ao.51.004678

Authors: Bin He, Lei Xi, Sean R. Samuelson, Huikai Xie, Lily Yang, Huabei Jiang

Institutions: University of Florida, Emory University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G231757908, G3687267199, G5988735914