Work

Coupling Signals between the Osteoclast and Osteoblast: How are Messages Transmitted between These Temporary Visitors to the Bone Surface?

Year: 2015

Type: review

Abstract: Skeletal mass is regulated by two key activities: bone removal (resorption) by hematopoietic lineage osteoclasts and bone matrix formation by mesenchymal lineage osteoblasts. During adult life, these activities occur sequentially on the same surface: a process termed as remodeling. Tiny packets of bone are removed by osteoclasts and replaced by new bone matrix produced by osteoblasts. This continual renewal process allows repair of mechanical imperfections and calcium homeostasis.

Source: Frontiers in Endocrinology

DOI: 10.3389/fendo.2015.00041

Authors: Natalie A. Sims, T. John Martin

Institutions: The University of Melbourne, St Vincent's Hospital Melbourne, St Vincents Institute of Medical Research

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,801

OpenAlex ID: W2053586178

FWCI: 1.889

Cites: 63

Cited by: 185

Related to: 10