Work

353: Generation of Treg-like Cells from CD4+CD25- T cells via Epigenetic Modification using a Demethylating Agent Decitabine

Year: 2008

Type: article

Abstract: Naturally-occurring regulatory T cells (nTreg) contribute to the maintenance of self-tolerance and have been reported to suppress autoimmunity and GvHD in mouse models. Major obstacles for their routine use in human clinical trials include the low number of Treg, low efficiencies of purification and severe limitations in ex vivo expansion without downregulating the expression of Foxp3 that is the master gene of Treg. Recent identification of demethylated CpG islands within the Foxp3 locus only in Treg lead us to investigate whether an FDA-approved demethylating agent, Decitabine, could be used to enhance expression of Foxp3 via an epigenetic effect and convert CD4+CD25- T cells into Treg.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2007.12.363

Authors: J. Choi, J. Ritchey, J.F. DiPersio

Institution: Washington University in St. Louis

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650