Work

Metabolic syndrome and mammographic density: The Study of Women's Health Across the Nation

Year: 2010

Type: article

Study design: Observational Study

Abstract: The metabolic syndrome (MetS) is associated with an increase in breast cancer risk. In our study, we evaluated whether the MetS was associated with an increase in percent mammographic density (MD), a breast cancer risk factor. We used linear regression and mixed models to examine the cross-sectional and longitudinal associations of the MetS and components of the MetS to percent MD in 790 premenopausal and early perimenopausal women enrolled in the Study of Women's Health Across the Nation (SWAN). In cross-sectional analyses adjusted for body mass index (BMI), modest inverse associations were observed between percent MD and the MetS [β = -2.5, standard error (SE) = 1.9, p = 0.19], abdominal adiposity (β = -4.8, SE = 1.9, p = 0.01) and raised glucose (β = -3.7, SE = 2.4, p = 0.12). In longitudinal models adjusted for covariates including age and BMI, abdominal adiposity (β = 0.34, SE = 0.17, p = 0.05) was significantly positively associated with slower annual decline in percent MD with time. In conclusion, our results do not support the hypothesis that the MetS increases breast cancer risk via a mechanism reflected by an increase in percent MD.

Source: International Journal of Cancer

DOI: 10.1002/ijc.25790

Authors: Shannon M. Conroy, Lesley M. Butler, Danielle Harvey, Ellen B. Gold, Barbara Sternfeld, Gail A. Greendale, Laurel A. Habel

Institutions: University of Hawaii Cancer Center, University of California, Davis, Colorado State University, Kaiser Permanente, Kaiser Permanente Oakland Medical Center, University of California, Los Angeles

Language: English

Topic: Digital Radiography and Breast Imaging

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute on Aging, National Cancer Institute, National Institute of Nursing Research, Office of Research on Women's Health

Awards: G1078949291, G1395245948, Study of Women's Health Across the Nation (SWAN) V: UCLA Site, Study of Women's Health Across the Nation (SWAN) V: Chicago site, G162523631, G1650445419, MENOPAUSAL TRANSITION IN BLACK AND WHITE WOMEN, G2069832255, G240534699, G2701036747, G2853426343, G2886598935, G2899798242, Study of Women's Health Across the Nation (SWAN) V: Coordinating Center, G3862244033, G4002206572, G4057997398, G4088562605, Study of Women's Health Across the Nation (SWAN) V: Central Laboratory, GYNECOLOGIC IMPACT OF THE MENOPAUSAL TRANSITION, G4492651742, G4847607846, G495529283, G5212787517, G5481793173, G6138161980, G6356525961, G6423459859, G6454223305, Study of Women's Health Across the Nation (SWAN V): Michigan Site, G6881890559, G7076164640, G711645435, G7265740541, G733855919, G776903742, G8334913947, Study of Women's Health Across the Nation(SWAN) V: Pittsburgh, G8865318642, G8907596937, Cancer Center Support Grant P30, G988252460

OpenAlex ID: W2053739461

FWCI: 1.474

Cites: 53

Cited by: 30

Related to: 10