Work

The Art of Engineering Viral Nanoparticles

Year: 2010

Type: article

Abstract: Viral nanotechnology is an emerging and highly interdisciplinary field in which viral nanoparticles (VNPs) are applied in diverse areas such as electronics, energy and next-generation medical devices. VNPs have been developed as candidates for novel materials, and are often described as "programmable" because they can be modified and functionalized using a number of techniques. In this review, we discuss the concepts and methods that allow VNPs to be engineered, including (i) bioconjugation chemistries, (ii) encapsulation techniques, (iii) mineralization strategies, and (iv) film and hydrogel development. With all these techniques in hand, the potential applications of VNPs are limited only by the imagination.

Source: Molecular Pharmaceutics

DOI: 10.1021/mp100225y

Authors: Jonathan K. Pokorski, Nicole F. Steinmetz

Institutions: Scripps Research Institute, Case Western Reserve University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funder: National Institute of Biomedical Imaging and Bioengineering

Awards: G2027850378, G379835839, G430619818, G766468881